What do we study?

Circadian rhythmicity is a fundamental aspect of temporal organization in essentially every cell in the body, and modulates much of physiology, biochemistry, and behavior.  In order to maintain daily cycles, cell-autonomous circadian oscillators drive rhythmic expression of approximately 5-10% of mRNAs to ultimately drive a wide range of rhythmic biological processes. Disruption of the circadian clock can have a severe influence on human health, ranging from psychiatric disorders, obesity, cardiovascular diseases, to certain types of cancer.
 
We are interested in understanding 1) how the circadian clock regulates the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude; and 2) how circadian clock utilizes rhythmically expressed proteins to regulate rhythmic physiology and behavior.  We use the mouse as an animal model system and integrate diverse approaches – genetics, genomics, bioinformatics, neuroscience, molecular/cellular biology, and sometimes mathematical modeling – to answer these questions.
 
 

What is new?

September 2021

Darrell Storholt joined the lab as a new lab tech. Welcome Darrell!

 

August 2021                 

Lin Miao, a new PHD student in the lab, has arrived from Los Angels. Welcome Lin!

 

July 2021

Preprint posted on bioRxiv – a cool collaboration with a plant biologist, Dr. Winkel! Crosstalk between Flavonoids and the Plant Circadian Clock: https://biorxiv.org/cgi/content/short/2021.07.15.452546v1

 
Follow @Kojima_CircaLab for more news!
 

Kojima Lab is Inclusive.

We are all different creatures. Our lab welcomes anybody who is passionate about science, regardless of your gender, religion, ethnicity, country of origin, cultural background, political views, or whatever else you can think of.