Circadian rhythmicity is a fundamental aspect of temporal organization in essentially every cell in the body, and modulates much of physiology, biochemistry, and behavior. In order to maintain daily cycles, cell-autonomous circadian oscillators drive rhythmic expression of approximately 5-10% of mRNAs to ultimately drive a wide range of rhythmic biological processes. Disruption of the circadian clock can have a severe influence on human health, ranging from psychiatric disorders, obesity, cardiovascular diseases, to certain types of cancer.
We are interested in understanding 1) how the circadian clock regulates the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude; and 2) how circadian clock utilizes rhythmically expressed proteins to regulate rhythmic physiology and behavior. We use the mouse as an animal model system and integrate diverse approaches – genetics, genomics, bioinformatics, neuroscience, molecular/cellular biology, and sometimes mathematical modeling – to answer these questions.
Kojima Lab is Inclusive.
We are all different creatures. Our lab welcomes anybody who is passionate about basic science research, regardless of your sex, gender, religion, ethnicity, country of origin, cultural background, political views, appearances, physical ability or whatever else you can think of.
What is new?
Juan Hernandez joined the lab as a lab tech. Welcome Juan!
Lin rocked at SRBR 2022! She had a poster presentation and a surprise video appearance!! Evan also had a poster but unfortunately could not make it due to COVID. Ben stepped in and filled an important role as a presenter!
Sherry + Evan’s paper is now out! A beautiful collaboration between plant and animal biologists: Mutations that alter Arabidopsis flavonoid metabolism affect the circadian clock https://onlinelibrary.wiley.com/doi/full/10.1111/tpj.15718
Follow us on Twitter @Kojima_CircaLab for more news!